Expression of aquaporin-1 in the choroid plexus in communicating and non-communicating hydrocephalic rats
نویسندگان
چکیده
Departamento de Anatomía, Anatomía Patológica e Histología, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Islas Canarias, Spain, Departamento de Biotecnología, Instituto de Investigación y Ciencias de Puerto del Rosario, Puerto del Rosario, Fuerteventura, Islas Canarias, Spain and Departamento de Farmacología, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Islas Canarias, Spain
منابع مشابه
Expression of Aquaporin 1 and 4 in the Choroid Plexus and Brain Parenchyma of Kaolin-Induced Hydrocephalic Rats
Objective Aquaporin (AQP) is a recently discovered protein that regulates water homeostasis. The present study examines changes in AQP 1 and 4 in kaolin induced experimental hydrocephalic rats to elucidate the pathophysiology of water homeostasis in the disease. Methods Hydrocephalus was induced by percutaneous intracisternal injection of kaolin. The brain parenchyma and choroid plexus were o...
متن کاملبررسی کیفی و کمی بیان پروتئین آکواپورین1 در شبکه کوروئید رت نژاد سویتار
Abstract Background: Choroid plexus (CP) is a branched structure made up of a single layer of epithelial cells and blood capillaries, forming the blood-CSF-barrier. The CSF (cerebrospinal fluid) is mainly produced from the CP. Aquaporin1 (AQP1), water channels that are highly expressed on the apical side of the membrane in choroid plexus, have a major role in mediating water transport across th...
متن کاملDifferent expressions of AQP1, AQP4, eNOS, and VEGF proteins in ischemic versus non-ischemic cerebropathy in rats: potential roles of AQP1 and eNOS in hydrocephalic and vasogenic edema formation
In this study, expressions of aquaporin (AQP) 1, AQP4, endothelial nitric oxide synthase (eNOS), and vascular endothelial growth factor in blood-cerebrospinal fluid (CSF) barrier and blood-brain barrier (BBB) are examined in rat choroid plexus and peri-infarcted hippocampal formation (HF) following systemic hyponatremia (SH) and permanent middle cerebral artery occlusion (pMCAO). These events a...
متن کاملAltered gravity downregulates aquaporin-1 protein expression in choroid plexus.
Aquaporin-1 (AQP1) is a water channel expressed abundantly at the apical pole of choroidal epithelial cells. The protein expression was quantified by immunocytochemistry and confocal microscopy in adult rats adapted to altered gravity. AQP1 expression was decreased by 64% at the apical pole of choroidal cells in rats dissected 5.5-8 h after a 14-day spaceflight. AQP1 was significantly overexpre...
متن کاملThe time course changes in expression of aquaporin 4 and aquaporin 1 following global cerebral ischemic edema in rat
BACKGROUND The aim of this global cerebral ischemia study was to study the changes in expression levels of aquaporin 4 (AQP4) and AQP1 over time. METHODS Sprague-Dawley type male rats were divided into six groups. Sham group and ischemia/reperfusion were performed on five other groups using the four-vessel occlusion model. Reperfusion was done 30 min after the occlusion, and each group was te...
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تاریخ انتشار 2015